Eric McCormack and Debra Messing
Eric McCormack was not the only actor, who was up for the role of "Will". John Barrowman (who later starred on "Desperate Houswifes") was first being considered by FOX, but didn't get it because he was "too straight", and the role went to Eric McCormack. Barrowman is gay in real-life, while McCormack is straight.