Alyssa Milano, Shannen Doherty and Holly Marie Combs
During her second leading role in a series, Shannen still was't able to play nice with the people working with her. The scandal began after Doherty managed to get a leading role in the series "Charmed" in 1998. Not only was she not able to get along with co-star Alyssa Milano, she even went so far as to start fighting with the producer of the popular TV show. She was fired after the third season of the show.